Pulsatilla is used for painful conditions of the male or female
reproductive system, such as painful periods. Pulsatilla is also
used for tension headache, hyperactive states, insomnia,
migraines, neuralgia, general restlessness, diseases and
functional disorders of the gastrointestinal GI and urinary
There are no information scientific studies available.
Pregnancy and Lactation: Refer to a Medical Herbalist.
There is insufficient reliable information available about the
effectiveness of pulsatilla.
Mechanism of Action:
The applicable parts of pulsatilla are the above ground parts.
Pulsatilla has analgesic, antispasmodic, sedative, and
antibacterial properties. It exhibits both uterine stimulant and
depressant activities. Pulsatilla contains ranunculin. Ranunculin
hydrolyzes to a toxic unstable compound called protoanemonin,
which readily dimerizes to nontoxic anemonin.84
Protoanemonin causes central nervous system (CNS) stimulation,
then paralysis in experimental animals. It also has antimicrobial
activity.85 Both anemonin and protoanemonin show some
evidence of sedative and antipyretic activity.84
Irritation of the kidney and urinary tract might be due to the
alkylating action of protoanemonin.85 Some evidence
suggests anemonin might be cytotoxic.84
Interactions with Herbs & Supplements:
Interactions with Drugs:
Interactions with Foods:
Interactions with Lab Tests:
Interactions with Diseases or Conditions:
Dr Clare’s Blends: 1 gm/day.
Oral: A typical oral dose is 120-300 mg dried above ground parts
three times daily. Alternatively one cup tea consumed three times
daily. To make tea, steep or simmer 120-300 mg dried above ground
parts in 150 mL water 5-10 minutes, strain,84 0.12-0.3
mL of the liquid extract, 1:1 in 25% alcohol, has been used three
times daily.84 0.3-1 mL of the tincture, 1:10 in 40%
alcohol, has been used three times daily.84
Topical: No typical dosage.
Specific References: PULSATILLA
84. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A
Guide for Healthcare Professionals. London, UK: The
Pharmaceutical Press, 1996.
85. Blumenthal M, ed. The Complete German Commission E
Monographs: Therapeutic Guide to Herbal Medicines. Trans. S.
Klein. Boston, MA: American Botanical Council, 1998.